<b>The effect of ovariectomy on hemodynamic functions and the level of nitric oxide metabolites in the heart of rats</b>

Background. A higher prevalence of cardiovascular disorders has been observed in women after menopause. This study aimed to determine the long-term effects ovariectomy on hemodynamic functions and level nitric oxide metabolites (NOx) heart tissue ovariectomized rats. Methods. Fourteen female Wistar rats were divided into two groups (n=7 each group) control (OVX). OVX rat model was induced using dorsolateral skin incision method. Cardiac function indices, including left ventricular developed pressure (LVDP), peak rate positive changes (+dp/dt), negative (-dp/dt) measured at time systole hearts 11 months ovariectomy. Serum levels NOx end study. Results. At study, had lower LVDP (19%, P=0.001), +dp/dt (30%, P&lt;0.001) -dp/dt (23%, P=0.004) than group. In addition, group serum P=0.021) compared group; also by 31% rats, but it not statistically significant (P=0.056). Conclusion. Long-term disrupts cardiac which is associated with decreased serum. Practical Implications. Our findings indicated impaired following estrogen deficiency These results can be used prevent treat disease post-menopausal women. However, these need confirmed humans.